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Due to significant beneficial cardiovascular effects and improved glycemic control, GLP-1 RAs are now recommended in type 2 diabetes patients with increased glycosylated hemoglobin A1c (HbA1c) level, alongside with first-line therapy and even with insulin treatment

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Typical adult doses range from 250 mg to 750 mg taken twice daily, but exact dosing depends on the condition

Gastrointestinal side effects also amplify, potentially leading to severe nausea, vomiting, or inadequate nutrition

In rabbits and cynomolgus monkeys administered semaglutide during organogenesis, early pregnancy losses and structural abnormalities were observed at below the MRHD (rabbit) and 5-fold or greater the MRHD (monkey)